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1169630-40-3
Ste-γ-Glu-AEEA-AEEA-OSU
Overview
Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU
CAS: 1169630-40-3
Cat. No. : LK0065
M. W. : 830.96
Synonyms: Ste-Glu-AEEA-AEEA-OSU；Semaglutide Impurity 141；C18-Glu(AEEA-AEEA-OSu)-OH；Ste-Glu(AEEA-AEEA-OSu)-OH；OH-Ste-Glu(AEEA-AEEA-OSu)-OH；HO-Ste-Glu(AEEA-AEEA-OSu)-OH
IUPAC Name: (S)-22-carboxy-1-((2,5-dioxopyrrolidin-1-yl)oxy)-1,10,19,24-tetraoxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontan-41-oic acid
InChIKey: DVGUZQKRMQLDDD-HKBQPEDESA-N
SMILES: O=C(CCCCCCCCCCCCCCCCC(N[C@H](C(O)=O)CCC(NCCOCCOCC(NCCOCCOCC(ON1C(CCC1=O)=O)=O)=O)=O)=O)O
PDF:
Purity: ≥ 85.0%/nAppearance: white to light yellow solid/nStorage conditions: sealed, frozen (-20℃ ± 5℃)
Product Use

Ste-γ-Glu-AEEA-AEEA-OSU (CAS: 1169630-40-3), as the side chain of semaglutide, can be used in the semi-synthetic recombinant fermentation process of semaglutide, this product introduces crucial segments, including the 18-carbon fatty acid side chain, AEEA-AEEA, and glutamic acid, to confer a long-acting effect. It can effectively avoid racemization and degradations, increase yield, and improve product purity. This is achieved by removing the tert-butyl group before coupling, thus eliminating the need to remove this protection group via TFA.

Product Specification

Excellent Morphological Properties: solid powder with good stability./nHigh Purity and Content: tris-acid < 5%, β-alanine impurity < 0.1%./nComprehensive Quality Studies: able to perform comprehensive quality studies according to the client's requirements, including related substances, residual solvents, genotoxic impurities, inorganic impurities, structure identification, and stability testing, etc. All the methods are well validated and can be transferred to clients. The related impurity references can also be provided.

General Information
Safety & Regulations
Product Number LK0065
Purity ≥ 85.0%
Molecular Formula C39H66N4O15
Physical State off-white solid
Storage Recommended storage temperature: -20C, Keep refni gerated and sealed.
Molecular Weight 830.96
CAS RN 1169630-40-3
GHS Pictogram Ste-γ-Glu-AEEA-AEEA-OSU
Signal Word Warning
Hazard Statements H315 (100%)-H319 (100%)-H335 (100%)
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GHS Hazard Statements
Precautionary Statements P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
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GHS Precautionary Statements
Product Relate
Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH
1662688-20-1
Fmoc-L-Lys[Oct-(otBu)-γ-Glu-(otBu)-AEEA-AEEA]-OH
Ste-γ-Glu-AEEA-AEEA-OSU
1169630-40-3
Ste-γ-Glu-AEEA-AEEA-OSU
tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu
1118767-16-0
tBuO-Ste-γ-Glu(AEEA-AEEA-OH)-OtBu
Fmoc-His-Aib-OH
1446013-07-5
Fmoc-His-Aib-OH
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
1890228-73-5
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH

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GHS Precautionary Statements
Precautionary Statements-General
CodePhrase
P101If medical advice is needed, have product container or label at hand.
P102Keep out of reach of children.
P103Read label before use.
Prevention
CodePhrase
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211Do not spray on an open flame or other ignition source.
P220Keep/Store away from clothing/combustible materials.
P221Take any precaution to avoid mixing with combustibles.
P222Do not allow contact with air.
P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.
Response
CodePhrase
P301+P310If swallowed: Immediately call a poison center or doctor.
P303+P361+P353If on skin (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310Immediately call a poison center or doctor.
Storage
CodePhrase
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P406Store in corrosive resistant/container with a resistant inner liner.
Disposal
CodePhrase
P501Dispose of contents/container to an approved waste disposal plant.
×
GHS Precautionary Statements
Precautionary Statements-General
CodePhrase
P101If medical advice is needed, have product container or label at hand.
P102Keep out of reach of children.
P103Read label before use.
Prevention
CodePhrase
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211Do not spray on an open flame or other ignition source.
P220Keep/Store away from clothing/combustible materials.
P221Take any precaution to avoid mixing with combustibles.
P222Do not allow contact with air.
P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.
Response
CodePhrase
P301+P310If swallowed: Immediately call a poison center or doctor.
P303+P361+P353If on skin (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310Immediately call a poison center or doctor.
Storage
CodePhrase
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P406Store in corrosive resistant/container with a resistant inner liner.
Disposal
CodePhrase
P501Dispose of contents/container to an approved waste disposal plant.